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forty eight These translocations may possibly happen in the context of advanced karyo forms. The commonest rearrangements entail 13q14, with various companions, as well as the IGH locus. The genes most commonly rearranged with IGH are BCL2
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translocations or amplifications on top of the genomic alterations previously present in the initial CLL, but lack the widespread mutations observed in Principal DLBCL indicating which they may possibly correspond to another biological classification.
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